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TPO-Ab positivity, often used as a marker of thyroid autoimmunity, has been associated with elevated pro-inflammatory cytokines, including interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-) (19, 20), which can have systemic effects beyond the thyroid gland (21, 22)

Helicobacter pylori activates the TLR2/NLRP3/caspase-1/IL-18 axis to induce regulatory T-cells, establish persistent infection and promote tolerance to allergens